Synthesis and Characterization of some Tetrazole Derivatives and Evaluation of their Biological Activity

This research included synthesizing a series of heterocyclic compounds where the compound 2-chloroacetohydrazide was synthesized from ethyl chloroethanoate with Hydrazine hydrate 95%. The reaction carried out in cold condition. 2-(pyrimidin-2-ylamino)acetohydrazide prepared by A1 2-amino pyrimidine absolute ethanol using Potassium hydroxide (KOH); then 2-(pyrimidin-2-ylamino) acetohydrazide different aldehydes to produce Schiff bases derivatives A3 –A14 which introduced two synthetic methods first synthesized. Then tetrazole [A15-A19] were hydrozone reactor (Schiff bases) [A3-A14] base sodium azide. In second way, 2, 3-dihydroquinozoline-4-one [A20-A24] interaction some Schiff's third step anthralenic acid (2-amino benzoic acid) 1,4-dioxane as solvent; diagnosed spectral methods, such UV, FTIR, 1H-NMR and quantitative analysis elements (C.H.N.S.). Some on growth four types bacterial isolates known be resistant antibiotics studied. Amoxicillin Ampicillin used control samples, showed good inhibiting efficacy against bacteria (Escherichia coli, Klebsiella pneumonia, Staphylococcus aureus, epidermidis)